Cell-Laden Nanocellulose/ Chitosan-Based Bioinks for 3D Bioprinting
3D bioprinting has recently emerged as a very useful tool in tissue engineering and regenerative medicine. Our lab is developing a nanocellulose/chitosan-based bioink, that is compatible with a 3D extrusion-based bioprinting technology, to design and engineer constructs for bone tissue engineering and regeneration applications. These bioinks are biocompatible and printable at an optimized range of printing pressure that does not compromise cell viability, and the presence of CNCs promotes greater osteogenesis of MC3T3-E1 cells in chitosan scaffolds. The versatility of this CNCs-incorporated chitosan hydrogel makes it attractive as a bioink for 3D bioprinting to engineer scaffolds for bone tissue engineering and other therapeutic applications.
Panita Maturavongsadit, Lokesh Karthik Narayanan, Parth Chansoria, Rohan Shirwaiker, S. Rahima Benhabbour*. Cell-Laden Nanocellulose/Chitosan-Based Bioinks for 3D Bioprinting and Enhanced Osteogenic Cell Differentiation, ACS Applied Bio Materials. 2021, https://doi.org/10.1021/acsabm.0c01108 .