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Thermo-/pH-Responsive Chitosan-Based Hydrogel for Tissue Regeneration Applications

Our lab has developed an injectable hydrogel with physical and mechanical properties that can mimic the bone microenvironment and promote bone regeneration. The injectable hydrogel is prepared with FDA-approved thermogelling biopolymers, chitosan and cellulose nanofibers/nanocrystals (CNFs/CNCs)). The chitosan solution can undergo sol-gel transition at body temperature, and CNFs/CNCs are used as an additive nanomaterial to enhance the mechanical properties of the chitosan gel and mimic bone tissue properties.

Cellulose nanocrystals (CNCs) can significantly improve the gelation kinetics and mechanical properties of the injectable chitosan hydrogel. This novel chitosan-CNC based injectable and biodegradable scaffold can be administered as a stable solution containing osteoblast cells and can promote cell viability and transformation for bone and tissue engineering. This hydrogel is also being investigated as a scaffold for induced neural stem cells for treatment of glioblastoma multiforme (GBM).

Jasmine L. King, Roopali Shrivastava, Pooja D Shah, Panita Maturavongsadit, S. Rahima Benhabbour*, Injectable pH and Thermo-Responsive Hydrogel Scaffold with Enhanced Osteogenic Differentiation of Preosteoblasts for Bone Regeneration, Pharmaceutics, 2023, 15, 2270,

Panita Maturavongsadit, Gayane Paravyan, Roopali Shrivastava, S. Rahima Benhabbour*. Thermo-/pH-Responsive Chitosan-Cellulose Nanocrystals Nased Hydrogel with Tunable Mechanical Properties for Tissue Regeneration Applications, Materialia, 2020, 12, 100681,